Category · Updated 2026

Fiber & digestion supplements

GLP-1 medications slow gastric emptying, which — combined with reduced food (and fiber) intake — causes constipation in roughly one in three patients. Psyllium, magnesium, and targeted prebiotics fix it. These are the products worth stocking.

How we picked

  • Evidence-backed active ingredient (psyllium, magnesium citrate/oxide, PHGG)
  • Clear dosing — grams per serving, not blends hidden behind proprietary formulas
  • No added sugar or unnecessary stimulant laxatives
  • Third-party verified purity when possible
  1. #1 Editor's pick
    4-in-1 Psyllium Fiber — Metamucil

    Metamucil

    4-in-1 Psyllium Fiber

    The gold-standard soluble fiber — 3 g psyllium per dose

    4.7

    $0.30 / serving

    • Decades of clinical data — the most-studied fiber supplement
    • Slows gastric emptying → smooths post-meal glucose
    • Available at every drug store
    • Texture takes getting used to (thickens fast)
  2. #2 Top rated
    Magnesium Bisglycinate — Thorne

    Thorne

    Magnesium Bisglycinate

    200 mg chelated magnesium — the gentle form for daily use

    4.7

    $0.42 / serving

    • Bisglycinate is the gentlest magnesium form — no laxative surge
    • NSF Certified for Sport (safe for tested athletes)
    • Physician-grade brand used by Mayo Clinic and Cleveland Clinic
    • Won't help acute constipation as fast as citrate
  3. #3 Top rated
    Calm Magnesium Citrate — Natural Vitality

    Natural Vitality

    Calm Magnesium Citrate

    The best-selling magnesium powder — 325 mg per scoop

    4.6

    $0.60 / serving

    • Two-purpose: fixes constipation AND improves sleep
    • Citrate form has the best bioavailability + laxative action
    • Pleasant citrus flavor — easier than horse-pill magnesium tablets
    • Too high a dose = loose stools (start with half a scoop)
  4. PHGG Prebiotic Fiber — Regular Girl

    Regular Girl

    PHGG Prebiotic Fiber

    Tasteless, dissolvable prebiotic + probiotic — mixes into anything

    4.5

    $1.15 / serving

    • Zero taste, zero texture — mixes into coffee, water, protein shakes
    • PHGG is the gentlest soluble fiber (won't cause bloating)
    • Adds beneficial probiotic strains too
    • More expensive per gram than psyllium
  5. Prebiotic Fiber Powder — Benefiber

    Benefiber

    Prebiotic Fiber Powder

    3 g wheat-dextrin fiber — dissolves clear in any liquid

    4.5

    $0.22 / serving

    • Truly tasteless and texture-free — dissolves like water
    • Cheapest per-serving fiber in our lineup
    • Available at every drug store and grocery
    • Contains wheat (not gluten-free — despite marketing)
  6. DS-01 Daily Synbiotic — Seed

    Seed

    DS-01 Daily Synbiotic

    24-strain probiotic + prebiotic — clinically validated blend

    4.4

    $1.83 / day

    • Only probiotic with published human clinical trial data at this dose
    • Capsule-in-capsule design survives stomach acid — most don't
    • Environmental-refill packaging
    • Slower to take effect than a laxative or fiber (weeks, not days)

Best for a specific use case